Nomenclature of Cyclic Peptides

Corresponding Author: Gerard P. Moss

International Union of Biochemistry and Molecular Biology
International Union of Pure and Applied Chemistry

Chemical Nomenclature and Structure Representation Division
IUBMB-IUPAC Joint Commission on Biochemical Nomenclature

These recommendations extend rule 3AA-19.5 of the Nomenclature and Symbolism for Amino Acids and Peptides (Recommendations 1983) to cover all classes of cyclic peptides. They include rings generated from an acyclic peptide by formation of a peptide or ester bond; by a disulfide link; or by a new carbon carbon, carbon-nitrogen, nitrogen-oxygen or carbon-sulfur bond (not esters or amides). These new bonds are indicated by the prefix anhydro, cyclo or epoxy, or combinations of them. The inclusion of modified standard amino acids or amino acids not related to standard amino acids is considered. Any stereochemistry generated by ring formation is indicated using standard organic conventions.

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