Vol. 26 No. 2
March-April 2004

Analog-Based Drug Discovery

The Chemistry and Human Health Division Committee has reviewed the project proposal Analog-Based Drug Discovery and has approved the project as one of the divisional activities. The international team-work started in January 2003. The project is part of the work of the Subcommittee on Medicinal Chemistry and Drug Development.

Analogs of drugs play an important role in the evolution of drug discoveries. Statistically, every second drug is an analog, therefore, it is of interest to analyze the relationship of these drugs to the pioneer discoveries and to each other.

The goal of this project is publication of a reference book for medicinal chemists and students that provides an easily usable overview of drug-analogs and their role in medicinal chemistry.

• The book will consist of the following chapters, to be written by the persons listed:
• Introduction (Robin Ganellin)
• Optimizing Drug Therapy by Analogs (Janos Fischer)
• Analogs as Means of Discovering New Drugs (Camille G. Wermuth)
• Drug Likeness and Analog-Based Drug Discovery (John Proudfoot)
• Case Studies
  • Lacidipine (Giovanni Gaviraghi)
  • Pantoprazole (Jorg Senn-Bilfinger)
  • Esomeprazole (Per Lindberg)
  • Moxifloxacin (Uwe Petersen)
  • Azithromycin (Miljenko Dumic)
  • Drospirenone (Rudolf Wiechert)
  • Bisphosphonates (Eli Breuer)
  • Glucocorticoids (Zoltan Tuba)
• Table of Drug-Analogs (Janos Fischer)
• Subject Index

According to the schedule, the final manuscript will be ready by 30 June 2004. Proposals and further case studies are welcome.

For more information, contact the Task Group Chairman Janos Fischer<[email protected]>.

www.iupac.org/projects/2002/2002-051-1-700.html