Project Details Solubility of Benzoic Acid and Substituted Benzoic Acids in Both Neat Organic Solvents and Organic Solvent Mixtures (Supplement to Solubility Data Series Volume 99)

Project No.:
2021-023-1-500
Start Date:
16 September 2021
End Date:

Objective

This volume be a supplement to Volume 99 in the IUPAC-NIST Solubility Data Series*, which was published in 2013 (https://iupac.org/project/2013-018-1-500). During the past 8 years there have been many published papers that have reported experimental data for benzoic acid and its derivatives. The supplement will include more than 750 additional data tables. The solubility data contained in the additional data tables appeared in the literature after Volume 99 was published. The additional data tables provide independent experimental data for several of the solute-solvent combinations contained in Volume 99, which allows for a more in depth critical evaluation and determination of measurement uncertainties than was possible in 2013 when Volume 99 was published.

* link to SDS page

Description

This volume update published Volume 99 (https://doi.org/10.1063/1.4816161) in the IUPAC-NIST Solubility Data Series, which was published in 2013. During the past 8 years there have been many published that have reported experimental data for benzoic acid and its derivatives. Experimentally determined solubility data for benzoic acid and more than 51 substituted benzoic acids dissolved in neat organic solvents and well-defined binary and ternary organic solvent mixtures retrieved from the published chemical, engineering and pharmaceutical literature covering the period between 2013 to the end of 2021.

The compiled solubility data will be of interest to practicing scientists working in the industrial manufacture sector because substituted benzoic acids and benzoic acid derivatives are used as starting materials in the synthesis of several important compounds, including both dyes and medicinal compounds. For example, the 2-hydroxy-deriviative of benzoic acid (commonly known as salicylic acid) is a nonsteroidal anti-inflammatory drug (NSAID) used to alleviate aches and pains, and is an important ingredient in many over-the-counter and prescription skin-care products for the treatment of acne, psoriasis, corns, and seborrhoeic dermatitis. Salicylic acid is also found in shampoos to control dandruff and dry scalp. Its methyl ester, methyl salicylate, can be applied topically as a liniment to relieve joint and muscle pains. Ester derivatives 5-amino-salicyclic acid (also known by its medicinal name of mesalazine) are used in the treatment and management of Crohn’s disease and ulcerative colitis. Other pharmaceutically important benzoic acid derivatives or medicinal compounds synthesized from benzoic acid derivatives include 2-acetoxybenzoic acid (medicinal name is aspirin), 4-aminobenzoic acid, and N-phenyl-2-aminobenzoic acids (fenamate class of nonsteroidal anti-inflammatory drugs, NSAIDs).

Progress

> link to Subcommittee page

Page last updated 16 Sep 2021