Project Details Successful Drug Discovery Vol. 4

Project No.:
2018-001-3-700
Start Date:
01 July 2018
End Date:
Division Name:
Chemistry and Human Health Division
Division No.:
700

Objective

The third volume of “Successful Drug Discovery” will be published in April 2018 by Wiley-VCH. The new project continues to present new drug discoveries: small-molecule-, peptide- and protein-based drugs. This will include both pioneer drugs (first in class drugs) and drug analogues (follow on drugs) in a range of therapeutic areas. The major part of the book is devoted to case histories of new drug discoveries described by their key inventors.

Description

The following chapters are planned:

  1. Molecular Targets of Drugs (John P. Overington, Medicines Discovery Catapult, UK)
  2. Physicochemical Parameters of Recently Approved Oral Drugs (Andreas Ritzén, Drug Design, LEO Pharma, Denmark)
  3. Orally Active Peptide-based Drugs (John Philip Mayer, University of Colorado)
  4. Dopamine Partial Agonists – Discovery, Evolution and Therapeutic Potential (Marlene Jacobson and Wayne Childers, Temple University, Philadelphia, USA)
  5. Antibody-Drug-Conjugates: Empowering Antibodies for the Fight against Cancer (Nicolas Joubert, Université de Tours, France)
  6. PCSK9 Antagonists – Discovery and Therapeutic Potential (Ayesha Sitlani, Merck Research Labs., Kenilworth, NJ, USA)
  7. Discovery of Etelcalcetide for the Treatment of Secondary Hyperparathyroidism in Patients with Chronic Kidney Disease on Hemodialysis (Derek Maclean and Amos Baruch)
  8. Development of Lenvatinib, an Angiogenesis Inhibitor Targeting VEGF Receptors and FGF Receptors (Akihiko Tsuruoka, Eisai Co. Ltd., Japan)
  9. Ocrelizumab : A New Chapter for Treatment of Multiple Sclerosis (Andrew Chan, Genentech, San Francisco, USA)
  10. The Story of Rucaparib/Rubraca (Bernard T. Golding, Newcastle University, UK)
  11. Discovery and Development of Venetoclax, a Selective Antagonist of BCL-2 (Wayne Frairbrother, Genentech and Abbvie, USA)

Progress

Project announcement published in CI Oct 2018; https://doi.org/10.1515/ci-2018-0417

Page last update 8 Nov 2018