Project Details Critical compilation of acid pKa values in polar aprotic solvents

Project No.:
2015-020-2-500
Start Date:
01 May 2016
End Date:

Objective

The objective is to summarize and critically evaluate the data on ionization constants of acids (pKa data) available in a selection of polar aprotic solvents, which are either (1) the most popular solvents for pKa determination or (2) have properties specifically suitable for determination of pKa values of certain compound classes. The outcome of the work will be a compilation together with critical evaluation of pKa values (published as an article in Pure and Applied Chemistry). The tentative solvent selection is the following: MeCN, DMSO, DMF, pyridine, acetone. In the polar aprotic solvents almost full coverage of measured compounds will be possible.

Description

The objective is to summarize and critically evaluate the data on ionization constants of acids (pKa data) available in a selection polar aprotic of solvents, which are either (1) the most popular solvents for pKa determination or (2) have properties specifically suitable for determination of pKa values of certain compound classes. The outcome of the work will be a compilation together with critical evaluation of pKa values (published as article in Pure and Applied Chemistry). The tentative solvent selection is the following:

MeCN, DMSO, DMF, Pyridine, Acetone.

In the polar aprotic solvents almost full coverage of measured compounds will be possible.

Progress

Page last update 19 May 2016