Project Details Nanomaterials in Human Health: The Trends and Future

Project No.:
2014-013-1-700
Start Date:
01 May 2014
End Date:
01 October 2014
Division Name:
Chemistry and Human Health Division
Division No.:
700

Objective

The immense interest in research on nanomaterials has already led to explosion of discoveries in nanotechnology, which are quickly moving out of the laboratory into commercial products. New materials engineered to a nanoscale can take on unique physico-chemical properties, enabling breakthroughs in many applications. The functional nanomaterials science is evolving rapidly in many fields, which raises some safety concerns on adverse health consequences of unintended human exposure to nanomaterials. Most of the studied nanomaterials can be fabricated using a combination of well-established chemistries, however, in order to drive further development of nanotechnology to fully realize its potential, there are still many critical research areas that need immediate attention of scientists.

Therefore, the objective of this project is to provide a two-day workshop, with a broad critical discussion on cutting edge nanotechnology methods and concepts based on polymers, lipids, conjugates, and advanced multicomponent nanoengineered systems containing all types of cargos used in wide range of applications. The workshop will be provided for up to 40 people and the registration will be free of charge. The specific aim is to have at least 25 participants from the young generation of researchers (i.e., PhD students), 10 leading academics from the field and 5 industry and health and safety regulatory representatives.

Description

The presented NANOMATERIALS workshop is relevant to two ongoing IUPAC projects: 2013-007-1-700 and 2010-051-1-700. Both deal with various aspects of nanomaterial preparation and advances in immunochemistry and applications to human health. In this workshop, we intend to critically assess the very timely and popular nanomaterials topic within broader professional networks. This will catalyze discussions among nanomaterial synthesis and safety experts in academia and industry. We’d like to create opportunities for collaboration and to strengthen the valuable relationship between basic and applied research in the field of nanomaterial science. Consequently, we intend to improve the image of chemistry in the scientific society and public. It will demonstrate IUPAC’s concern for the safe design of chemical products for the benefit of humanity.

The IUPAC NANOMATERIALS workshop will emphasize the following aspects:

  1. New synthetic methodologies for the preparation of the nanomaterial – with special focus on robust, high-throughput, industrially scalable chemical approaches to produce novel materials. We will highlight novel surface modifications and immobilization strategies to conjugate biorecognition elements to the nanoparticle surface.
  2. Nanomaterial characterization – The merits of standard and novel approaches to characterize the morphology, structure and nanotoxicity of the new material will be discussed. Analytical methods for basic characterization, quality control and for the assessment of the function of the immobilized bio-recognition elements will be mentioned.
  3. Human Health Related Applications – Presented trends in the development of crucial pharmacological and relevant nanomaterial therapeutic applications of main nanodevices in human health applications. Special emphasis will be placed on drug delivery aspects for personalized treatments including pharmacokinetic, pharmacodynamic and toxicological behaviors.
  4. Biocompatibility – Parameters affecting the material chemical composition, surface behavior, solubility, size and other crucial parameters.
  5. Imaging and diagnostics – Future trends and research avenues to design the parameters enabling in-vivo and in-vitro imaging and features rendering the nanomaterial as useful biomedical diagnostics agents will be presented and discussed.

The project is well confined within IUPAC goals. It is designed to facilitate the research advances in nanotechnology and in the chemical sciences. This will be demonstrated on relevant examples from chemistry, medicine and biomedical science and common examples from every-day products. The workshop will have educational character and satisfy the educational needs of chemists, other scientists and wide public around the globe.

Progress

The workshop is scheduled for 15-16 Sep 2014 at Keynes College, University of Kent in Canterbury.
For more info, contact Vladimir Gubala at V.Gubala@kent.ac.uk or visit https://www.msp.ac.uk/research/iupacnanomat.html

Update, 19 Sep 2014 – The workshop and its program were thoroughly organized. The workshop took place on the pleasant university campus in Canterbury and had an international flair. Scientists originating from 8 different countries made their presentations and there were a lot of positive interactions between the participants. The program included 16 speakers and 15 poster presentations. The presentations which were up to date, interesting and concise, demonstrated that despite the many different approaches to the scaffolds and to the functionalization of nanoparticles, there are some common methodological rules as well as common problems relating to the stability of nanoparticles in biological systems and potential unwanted effects.

A report is published in a the Jan 2015 issue of Chemistry International, p. 31-32, https://dx.doi.org/10.1515/ci-2015-0125

Last updated 19 Oct 2015