Project Details Successful Drug Discoveries

Project No.:
Start Date:
01 September 2013
End Date:
30 April 2015
Division Name:
Chemistry and Human Health Division
Division No.:


The new project “Successful Drug Discoveries” is an extension of the completed project “Analogue-based Drug Discovery” affording three books published in 2006 (project 2002-051-1-700), 2010 (project 2008-013-1-700) and 2013 (project 2011-011-1-700) by Wiley-VCH. The book series focused on drug analogues. The plan of the new project is to present novel drugs that have been approved for use. This will include both pioneer drugs (first in class drugs) and drug analogues (follow on drugs) in a range of therapeutic areas. The new project has a broader scope, nevertheless, we want to preserve the structure of the completed book series.


The following chapters are planned:

  1. lorcaserin for the treatment of obesity (Brian Smith, Arena, USA)
  2. insulin analogues for the treatment of type I of diabetes (John M. Beals, Lilly, USA)
  3. telaprevir for the treatment of hepatitis C (Govinda Rao, Vertex, USA)
  4. pemetrexed antifiolate anticancer drug (Edward Taylor, Princeton University, USA)
  5. ingenol a protein kinase C activator for the treatment of actinic keratoses (Thomas Hogberg, Leo, Denmark)
  6. linagliptin for the treatment of type II of diabetes (Matthias Eckhardt and Thomas Klein, Boehringer Ingelheim, Germany)
  7. linaclotide, unique orally active peptide for the treatment of irritable bowel syndrome (Angelika Fretzen, Ironwood, USA)
  8. elvitegravir for the treatment of HIV (Hisashi Shikai, Japan Tobacco, Japan)
  9. eletriptan, an antimigraine drug (Martin Wythes, Pfizer, USA)
  10. perampanel, a new antiepileptic drug (Shigeki Hibi, Eisai, Japan)
  11. avanafil, a new PDE5 inhibitor (Koichiro Yamada, Tanabe-Mitsubishi, Japan)
  12. lixisenatide, a new GLP-1 agonist drug (Agneta Svedberg, Zealand, Denmark)
  13. cariprazine, a new antipsychotic drug (Bela Kiss, Richter, Hungary)
  14. dapagliflozin, a new drug for the treatment of the type II of diabetes (William Washburn, BMS, USA)

Further invitations are planned for the general aspects of drug discoveries and for drug class studies.

The majority of the above chapters describe new recently introduced drugs.


Project completed – the book edited by Janos Fischer and David P. Rotella has been published by Wiley-VCH, 2015, ISBN: 9783527336852.


Book announcement published in Chem. Int. Jan 2016, p. 29;

Last update: 11 Jan 2016