Project Details Glossary of terms used in neurotoxicology and reproductive/developmental toxicology

Project No.:
Start Date:
01 April 2013
End Date:
01 August 2015


An IUPAC “Glossary of Terms used in Toxicology” was published as an “IUPAC Recommendation” in 1993 ( and updated in 2007 ( The “IUPAC Recommendation for Terminology used in Ecotoxicology” followed in 2009 (, and for “Terminology used in Immunotoxicology” in 2012 (, both compiled in conjunction with others, including the members of the task group. Two further areas of toxicology have now been identified where there is new terminology for which there is, as yet, no authoritative glossary. The aim of this project is to compile such a glossary with a future aim of consolidating it with all existing IUPAC toxicology glossaries into a single comprehensive up-to-date IUPAC document that will then cover the diverse but related specialties and subspecialties of toxicology.


The Task Group will compile from the current toxicology literature a list of terms, related to neurotoxicology and reproductive / developmental toxicology, that need to be defined. Current definitions will be noted and used as a basis for new definitions to be written according to the IUPAC approved format. The Task Group consensus definitions will be submitted to international experts in neurotoxicology and reproductive / developmental toxicology to ensure that they conform to current usage. Once a final consensus has been agreed, the resultant glossaries will be submitted to PAC for consideration for publication. Once approved for publication, the definitions will be added to the consolidated IUPAC Glossary of Terms Used in Toxicology with its related database, and then will be disseminated as part of this glossary.


Oct 2014 update – The definitions for an agreed list of neurotoxicology terms are being considered by expert reviewers. Following the reviewers’ comments, the definitions will be revised by the Working Group for clarity and conformity to current usage. The reproductive / developmental toxicology glossary is being developed separately following the same procedure.

January 2015 – the provisional recommendations titled ‘Glossary of Terms Used in Neurotoxicology’ is made available for public review until 31 May 2015.

August 2015 – recommendations published: IUPAC Glossary of terms used in neurotoxicology (IUPAC Recommendations 2015), Pure Appl. Chem. (2015),

December 2015 – the second ‘Glossary of Terms in Reproductive and Developmental Toxicology’ is available as provisional recommendations and for public review until 30 April 2016.

When this is finalized, all Glossaries (Toxicokinetics 2003, Toxicology 2nd ed. 2007, Ecotoxicology 2010, Immunotoxicology 2012, and Neurotoxicology 2015) will be collected, made compatible in style, updated and revised, etc. for publication in book form by RSC (see project 2013-006-1-700).

October 2016 – the ‘Glossary of Terms in Reproductive and Developmental Toxicology (IUPAC Recommendations 2016)’ is published as PAC 88(8), pp. 713-830, 2016; (online 19 Oct 2016).

Page last updated 20 Oct 2016