Project Details Human Drug Metabolism Database (hDMdb)

Project No.:
2011-018-1-700
Start Date:
01 September 2011
End Date:

Objective

Long term: To ultimately mount this database on the www so that it can be readily accessed and utilized by scientists around the world.

Immediate term: (i) To elaborate a detailed outline for the db that can be published and used within future grant applications to other funding sources which can then provide the significantly larger amounts of financing needed to actually reach the long term goal; and (ii) Set-up a working prototype on a common desk-top platform using one of today’s inexpensive software systems which have now evolved to be able to handle dbs of this size.

Description

This topic has previously been an IUPAC Project, namely 2000-010-1-700. Previous efforts led to a specific software-dependent outline accompanied by an attempt to devise a working prototype using Oracle. The legally cumbersome and expensive Oracle db shell is no longer needed for this type of undertaking (see immediate objectives noted above). The informational content of the db will remain the same as that proposed in the original submission which did include, even at that earlier point in time, a connected ‘bin’ for organizing genetic information relevant to human DM considerations.

Progress

Jan 2012 – project announcement published in Chem. Int. Jan-Feb 2012, p. 22

Feb 2014 – A revamped outline is nearing completion and efforts to mount a prototype will begin immediately thereafter.

Mar 2016 – The task group is currently re-evaluating the merit of establishing a hDMdb and reviewing the present resources in this arena and a survey of users from the public (NIH etc.), academic and private (small and big pharma) sectors while including representation from several countries besides the U.S.; and generate an article based upon these findings for PAC that can also be used to guide subsequent decisions about potentially proceeding with such a project with or without direct IUPAC involvement.

It is anticipated that this plan can nearly overlap or trail just behind the DM Terms project 2000-009-1-700.

Oct 2017 – The task group is conducting a survey across academe and the private sector to see if there is still high interest in potentially assembling such a resource/tool and plans to publish a white paper on this topic based upon the survey responses. The survey shall be completed during the 2nd Q 2018.

May 2018 – Progress was reviewed at the SC meeting this month and plan to complete this year has been outlined.

March 2019 – A general survey had been planned to assess the value of pursuing this type of database. A white paper summary for publication in PAC was planned as the project’s final deliverable at the end of 2018 or in early 2019. However, two factors changed this plan. First, conversations with several established colleagues as a prelude to the general survey, immediately made it clear that this type of database would indeed be very welcome by even the more ‘wealthy’ members of the pharmaceutical enterprise. Second, the US initiative to finally provide significant funding toward practical projects within the data science arena (DSA) for the purpose of ‘harnessing big data’ provides an avenue to actually pursue the hDMdb rather than to just assess and summarize its potential value so that someone else somewhere might then undertake such an effort. The project leader has submitted one application to a solicitation from this funding stream. More than 20 multidisciplinary investigators with interests in the DSA have been brought together for these submissions. If funding is granted, then the three-year goal will be to mount the hDMdb on the Internet in a non-profit manner for investigators from all countries to use at a minimal cost. The impetus initially created by the IUPAC Project System/Med. Chem. Subcommittee and its continuing catalytic role thereafter, will be clearly acknowledged on the database’s homepage. If funding cannot be garnered, then the initial project plan for a white paper summary will be issued prior to the year’s end.

Last update 18 June 2019