Project Details Explanatory dictionary of terms used in toxicology (Part 2)

Project No.:
2006-020-1-700
Start Date:
12 July 2007
End Date:
04 July 2018
Division Name:
Chemistry and Human Health Division
Division No.:
700

Objective

To enhance the original dictionary –project #2003-001-2-700– and add about 20 terms used in toxicokinetics with full explanations of the meaning and underlying concepts.

Description

In order to incorporate chemistry and merge toxicology into the terminology used in toxicokinetics in various scientific disciplines, a project entitled Glossary for toxicokinetics of chemicals (#2000-034-2-700) was initiated and the outcome published in 2004 (PAC Vol. 76, No. 5, pp. 1033-1082).

A related project aimed at creating an Explanatory Dictionary of Concepts in Toxicokinetics (#2003-001-2-700); the terms are selected from the 1st glossary and extended explanations of the concepts underlying the selected terms are proposed.

Following these two projects, a need to explain further terms has been identified. By doubling the entries in the pilot paper to include approximately 20 more, the work will be substantial enough to publish in book form. The task group will prepared the additional text and reorganize the overall work thematically.

The project consists of about 20 more terms to be explained. The project is designed to serve the current educational needs of chemists and other scientists and thus should be of global interest. A list of terms to be included in part 2 of the explanatory dictionary is given below.

Progress

project announcement publishedin Chem.Int. Nov 2007

Proposed list of terms to be included in the Explanatory Dictionary of Terms in Toxicology (part 2):

  • Aerobic, Anaerobic
  • Bio-accessibility, Bio-availability
  • Biomonitoring
  • Carcinogenicity
  • Ecotoxicology
    • Biodiversity
    • Species Imbalance
    • Environmental risk assessment
    • Ecological risk assessment
  • Endocrine modification
  • Hypersensitivity
  • Immunosuppression
  • Material Safety Data Sheet (MSDS) – principles of interpretation
  • Mutagenicity
  • Nanoparticles
  • Nanotoxicology
  • Biomolecular Surveying Methods
    • Genomics
    • Proteomics
    • Metabonomics
    • Metallomics
  • Particle Toxicology
  • Persistence
  • Reproductive toxicant
  • Risk Assessment and Management
    • Chemical Safety
  • Speciation
    • Chemical speciation
    • Biological speciation
  • Teratogenicity
  • Toxicity classification and labelling – principles

March 2009 – A manuscript is being prepared for publication in Pure Appl.
Chem
. A final document is submitted to public review comments until 31 August 2009.
> provisionalrecommendations (../../provisional/abstract09/nordberg_310809.html)

October 2009 – published by the same team and of interest to this project is a book titled ‘Concepts in Toxicology’, published by RSC (ISBN: 978-0-85404-157-2) – view detail

Feb 2010 – IUPAC recommendations titled ‘Explanatory dictionary of key terms in toxicology: Part II (IUPAC Recommendations 2010)’ published in Pure Appl. Chem., 2010, Vol. 82, No. 3, pp. 679-751, doi:10.1351/PAC-REC-09-03-01

Jan 2016 update – this task group will further explore collaborative work with the task group on “Risk assessment of effects of cadmium” (project 2009-034-2-700). In that project, there is the basis of a paper dealing with “Principles of Risk Assessment for Metal Toxicity”, taking Gunnar Nordberg’s paper as a model and generalizing for all metals the principles identified in approaching the risk assessment of potential cadmium exposures. That project has had to deal with fundamental points that should be discussed and presented in the form of recommendations both for risk assessment itself and for solving some of the inherent problems present in making a risk assessment for metal toxicity. A joint meeting will be held in the spring 2016.

Last update: 18 January 2016