Project Details Practical studies for Medicinal Chemistry - An integrating approach for developing countries

Project No.:
2004-028-1-700
Start Date:
01 September 2004
End Date:
25 January 2007
Division Name:
Chemistry and Human Health Division
Division No.:
700

Objective

To provide the developing countries with a practical textbook containing practical experiments to assist studies in Medicinal Chemistry – It should take into account the special characteristics of these societies, such as taking advantage of the natural resources, lack of economic means for obtaining reagents, materials, etc. The idea is to also provide a foundation for post graduate studies that will facilitate the training of medicinal chemists so that they can conduct research into the discovery and development of drugs to treat indigenous diseases, such as tuberculosis, malaria, leprosy, and Chagas. Since these diseases principally affect the developing countries and receive little attention in the pharmaceutical industry of the developed countries, it is important to assist the developing countries to tackle their own problems.

To prepare the book “Practical Studies for Medicinal Chemistry Students. An integrated approach for developing countries” – The book will be prepared in paper form and will also be accessible via the IUPAC web page, being able to download any or all of its pages free of charge.

Description

The text will be written in English but some texts will also be in Spanish and Portuguese, when provided by the authors. This allows accessibility to students who are not fluent in English. The text would be of integrating character, from disciplines that converge in R&D of Medicinal Chemistry: organic synthesis, natural product, isolation, structural identification, and structure-activity relationships; biological activities. The experiments provided would be such that they could be carried out with easily accessible starting materials (natural products from the area, for example) and economic reagents, and low-cost instrumentation and techniques.

These practical texts would be applicable to diseases which are indigenous to the developing countries, for example, isolation of products with antimalaria activity, based on products of natural origin; low-cost synthesis of antituberculosis products, etc.

The task group members are specialists in the different areas corresponding to the book material.An initial approach in Latin America and for Spanish- and Portuguese-speaking countries was recently presented by Dr. Barreiro and Dr. Fortes, within a R&D program, coordinated by A. Monge. This text will be the embryo of the future version to be prepared for IUPAC.

The favorable reception of this initiative allows for a more extensive proposal with universal character. The manual would be valid for universal use, regardless of the development stages of the societies.

Progress

Project announcement published in Chem.Int. Nov-Dec 2004

Online Outline:
Integrating Practical Studies

  • Chemical synthesis
  • Biological activity
  • Predictive calculation of A.D.M.E
  • Predictive calculation of solubility, …

Low Cost Practical Studies

  • Regarding equipment (instruments, apparatus, …)
  • Regarding reagents
  • Regarding software, …

Practical Studies Based on Natural Products and Products of Synthesis

  • Possibility to adapt experiments to native natural products


March 2005
– The project is progressing according to plan. A first report was presented in the Subcommittee Medicinal Chemistry meeting on 13 Feb 2005.
The call for submitting practical studies is set for 1 August 2005.

December 2006 – compilation completed
> see online resource

project completed

A book version was published in 2011 in three languages, Spanish, Portuguese and English, (by Universidad Nacional de Rio Cuarto, Rio Cuarto, Argentina ISBN 978-950-665-570-9), edited by Antonio Monge and C. Robin Ganellin and coordinated by Rosa Cattana. A review was published in Chem Int Sep-Oct 2013, pp. 21-22 (DOI 10.1515/ci-2013-0518)