Project Details Solubility data of compounds relevant to human health. Solubility of hydroxybenzoic acids and hydroxybenzoates

Project No.:
2002-036-1-500
Start Date:
01 January 2003
End Date:
01 March 2011
Division Name:
Analytical Chemistry Division
Division No.:
500

Objective

Series: Solubility Data Series; editor-in-chief: Mark Salomon

 Hydroxybenzoic acids and related compounds are pharmaceutically important substances. In particular, 2-hydroxybenzoic acid has been widely used as a medicine and a preservative for food products; 4-hydroxybenzoic acid alkyl esters have also been used as preservatives for food. The relation between the use of these substances and human health requires evaluation of the solubilities of 2-, 3-, and 4-monohydroxybenzoic acids and of 4-hydroxybenzoic acid alkyl esters in water, organic and mixed solvents. It is also suggested to evaluate the solubilities of: (a) 2- and 3-hydroxybenzoic acid in supercritical carbon dioxide containing organic solvents such as methanol and acetone; (b) monohydroxybenzoates, 2,3-, 2,4-, 2,5-, 2,6-, 3,4- and 3,5- dihydroxybenzoic acid salts of alkali, transition and rare earth metals in water and organic solvents.

Progress

> project announcement published in Chem. Int. 25(3), 2003

All of the solubility data of hydroxyl benzoic acids and hydroxybenzoates have been compiled. A total of 177 original studies treating ternary systems published from 1898 to 2001 has been carried out. The solubilities of hydroxyl benzoic acids and alkyl p hydroxybenzoates in water and in various alcohols could be statistically evaluated at various temperatures.
> Nov 2004 report update (pdf file – 11KB)

> May 2006 report update (pdffile – 14KB)

> July 2007 report update (pdffile – 13KB)

March 2011 – IUPAC-NIST Solubility Data Series. 90. Hydroxybenzoic Acid Derivatives in Binary, Ternary, and Multicomponent Systems. Part I. Hydroxybenzoic Acids, Hydroxybenzoates, and Hydroxybenzoic Acid Salts in Water and Aqueous Systems. J. Phys. Chem. Ref. Data 40, 013101 (2011); doi:10.1063/1.3525876 (130 pages)

Project completed

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