Project Details Solubility data of compounds relevant to human health. Solubility of substances related to urolithiasis

Project No.:
2002-035-1-500
Start Date:
01 January 2003
End Date:
18 May 2018
Division Name:
Analytical Chemistry Division
Division No.:
500

Objective

Series: Solubility Data Series; editor-in-chief: Mark Salomon

The prevention and treatment of crystal deposition in the human body are based on the understanding of the physico-chemical properties under lying the precipitation of the substances involved. Amongst these properties,the solubilities of the crystals are very important. In the scope of urolithiasis, there are more than 20 different types of kidney stones composed of calcium oxalate hydrates (mono-, di- and trihydrate), ammonium magnesium phosphate (struvite), calcium phosphates (hydroxyapatite and brushite), uric acid and urates, cystine and xanthine. Solubilities of these substances can be incorporated in databases of sophisticated software packages that permit solubility calculations in artificial urine solutions. The results of these simulations would lead to some understanding and/or useful suggestions regarding the cause, prevention and treatment of renal or bladder calculi. Nevertheless, proper modelling of the solubilities of these substances requires reliable solubility constants. Thus it is necessary to critically assess the literature values reported for these substances. Recently, two reviews on this subject have been published: [1] E. Königsberger and L.-C. Tran-Ho, Solubility of substances related to urolithiasis – Experiments and computer modelling. CurrentTopics in Solution Chemistry, 2:183-202 (1997).
[2] E. Königsberger and L.-C. Königsberger, Thermodynamic modelling of crystal deposition in humans. Pure Appl. Chem.,73: 785-797 (2001).

Progress

Project announcement published in Chem. Int. 25(3), 2003

Papers related to this project:
G. Sadovska, I. Kron and E. Königsberger. Solubility of uric acid in lithium chloride solutions. Monatsh. Chem., 134:787-790, 2003. [doi:10.1007/s00706-002-0588-2]

> Nov 2004 report update (pdffile – 10KB)

To be published as part of the IUPAC-NIST Solubility Data Series. in J. Phys. Chem. Ref. Data; estimated to be completed during 2006/7.

> May 2006 report update (pdffile – 13KB)

> July 2007 report update (pdffile – 8KB)
1 book and 2 book chapters related to the project were published recently:
Biomineralization- Medical Aspects of Solubility. E. Königsberger and L.C. Königsberger(eds.) Wiley, 2006, 284 pp.

– E. Königsberger and L.C. Königsberger. Solubility phenomena related to normal and pathological biomineralisation processes. In:Biomineralization – Medical Aspects of Solubility. E. Königsberger and L.C. Königsberger (eds.), John Wiley & Sons, 1-37, 2006.

– E. Königsberger and L.-C. Königsberger. Solubility and body fluids. In: Thermodynamics, Solubility and Environmental Issues. T. Letcher (ed.), Elsevier, 445-461, 2007.

> May 2018, recent publications
– Hill, M.G., Königsberger, E. and May, P.M. Mineral precipitation and dissolution in the kidney. American Mineralogist, 102, 701-710 (2017); https://doi.org/10.2138/am-2017-5778

– Wang, Z., Königsberger, L.C. and Königsberger, E. Solubility equilibria in the uric acid–ammonium urate–water system. Monatshefte für Chemie – Chemical Monthly, 149, 327-332 (2018); https://doi.org/10.1007/s00706-017-2107-5