Glossary and tutorial of xenobiotic metabolism terms used during small molecule drug discovery and development

Provisional Recommendations are drafts of IUPAC recommendations on terminology, nomenclature, and symbols, made widely available to allow interested parties to comment before the recommendations are finally revised and published in IUPAC’s journal Pure and Applied Chemistry.

This project originated nearly 15 years ago with the intent to produce a glossary of drug metabolism terms having definitions especially applicable for use by practicing medicinal chemists. A first-draft version underwent extensive beta-testing that, fortuitously, engaged international audiences having a wide range of disciplines involved in drug discovery and development. It became clear that inclusion of information to enhance discussions among this mix of participants would be even more valuable. The glossary’s present version retains a chemical structure theme while expanding tutorial comments directed toward bridging various perspectives that may arise for a given term during interdisciplinary communications. It is intended to be educational for early stage researchers, as well as being a useful resource for investigators at various levels who participate on today’s highly multidisciplinary, collaborative drug discovery teams.

Access full text – return comments to the corresponding Author: Paul Erhardt Paul.Erhardt@utoledo.edu

Comments by 31 December 2019

See all  Provisional Recommendations currently under review.

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