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Pure Appl. Chem., 2009, Vol. 81, No. 6, pp. 1051-1063

http://dx.doi.org/10.1351/PAC-CON-08-10-16

Published online 2009-05-05

Discovery of anticancer agents of diverse natural origin

A. Douglas Kinghorn1*, Esperanza J. Carcache de Blanco1, Hee-Byung Chai1, Jimmy Orjala2, Norman R. Farnsworth2, D. Doel Soejarto2, Nicholas H. Oberlies3, Mansukh C. Wani3, David J. Kroll3*, Cedric J. Pearce4, Steven M. Swanson2, Robert A. Kramer5, William C. Rose5, Craig R. Fairchild5, Gregory D. Vite5, Stuart Emanuel5, David Jarjoura6 and Frederick O. Cope6

1 College of Pharmacy, The Ohio State University, Columbus, OH 43210, USA
2 College of Pharmacy, The University of Illinois at Chicago, Chicago, IL 60612, USA
3 Research Triangle Institute, Research Triangle Park, NC 27709, USA
4 Mycosynthetix, Inc., Hillsborough, NC 27278, USA
5 Bristol-Myers Squibb, Pharmaceutical Research Institute, Princeton, NJ 08543, USA
6 Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA

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  • Bueno Pérez Lynette, Still Patrick C., Naman C. Benjamin, Ren Yulin, Pan Li, Chai Hee-Byung, Carcache de Blanco Esperanza J., Ninh Tran Ngoc, Thanh Bui Van, Swanson Steven M., Soejarto Djaja D., Kinghorn A. Douglas: Investigation of Vietnamese plants for potential anticancer agents. Phytochem Rev 2014. <http://dx.doi.org/10.1007/s11101-014-9335-7>
  • Kaur Kamalneet, Kumar Vinod, Sharma Anil Kumar, Gupta Girish Kumar: Isoxazoline containing natural products as anticancer agents: A review. European Journal of Medicinal Chemistry 2014, 77, 121. <http://dx.doi.org/10.1016/j.ejmech.2014.02.063>
  • Ren Yulin, Yuan Chunhua, Qian Yanrong, Chai Hee-Byung, Chen Xiaozhuo, Goetz Michael, Kinghorn A. Douglas: Constituents of an Extract of Cryptocarya rubra Housed in a Repository with Cytotoxic and Glucose Transport Inhibitory Effects. J. Nat. Prod. 2014, 77, 550. <http://dx.doi.org/10.1021/np400809w>
  • Tambama Penelope, Abegaz Berhanu, Mukanganyama Stanley: Antiproliferative Activity of the Isofuranonaphthoquinone Isolated from Bulbine frutescens against Jurkat T Cells. BioMed Research International 2014, 2014, 1. <http://dx.doi.org/10.1155/2014/752941>
  • Saeidnia Soodabeh, Abdollahi Mohammad: Antioxidants: Friends or foe in prevention or treatment of cancer: The debate of the century. Toxicology and Applied Pharmacology 2013, 271, 49. <http://dx.doi.org/10.1016/j.taap.2013.05.004>
  • Ren Yulin, Chai Heebyung, Goetz Michael, Kinghorn A. Douglas: A cytotoxic decahydronaphthalenylpropenal derivative and tetrahydrofuran lignans from the stems of Cameraria latifolia. Tetrahedron Letters 2013, 54, 4854. <http://dx.doi.org/10.1016/j.tetlet.2013.06.109>
  • Figueroa Mario, Raja Huzefa, Falkinham Joseph O., Adcock Audrey F., Kroll David J., Wani Mansukh C., Pearce Cedric J., Oberlies Nicholas H.: Peptaibols, Tetramic Acid Derivatives, Isocoumarins, and Sesquiterpenes from a Bionectria sp. (MSX 47401). J. Nat. Prod. 2013, 76, 1007. <http://dx.doi.org/10.1021/np3008842>
  • Bueno Pérez Lynette, Li Jie, Lantvit Daniel D., Pan Li, Ninh Tran Ngoc, Chai Hee-Byung, Soejarto Djaja Djendoel, Swanson Steven M., Lucas David M., Kinghorn A. Douglas: Bioactive Constituents of Indigofera spicata. J. Nat. Prod. 2013, 76, 1498. <http://dx.doi.org/10.1021/np400567c>
  • Acuna Ulyana Munoz, Shen Qi, Ren Yulin, Lantvit Daniel D., Wittwer Jennifer A., Kinghorn A. Douglas, Swanson Steven M., Blanco Esperanza J. Carcach: Goyazensolide Induces Apoptosis in Cancer Cells in vitro and in vivo. International J. of Cancer Research 2013, 9, 36. <http://dx.doi.org/10.3923/ijcr.2013.36.53>
  • Ayers Sloan, Ehrmann Brandie M., Adcock Audrey F., Kroll David J., Carcache de Blanco Esperanza J., Shen Qi, Swanson Steven M., Falkinham Joseph O., Wani Mansukh C., Mitchell Sheila M., Pearce Cedric J., Oberlies Nicholas H.: Peptaibols from two unidentified fungi of the order Hypocreales with cytotoxic, antibiotic, and anthelmintic activities. J. Pept. Sci. 2012, 18, 500. <http://dx.doi.org/10.1002/psc.2425>
  • Kim Hyunjung, Lantvit Daniel, Hwang Chang Hwa, Kroll David J., Swanson Steven M., Franzblau Scott G., Orjala Jimmy: Indole alkaloids from two cultured cyanobacteria, Westiellopsis sp. and Fischerella muscicola. Bioorganic & Medicinal Chemistry 2012, 20, 5290. <http://dx.doi.org/10.1016/j.bmc.2012.06.030>
  • Ren Yulin, Acuña Ulyana Muñoz, Jiménez Francisco, García Ricardo, Mejía Melciades, Chai Heebyung, Gallucci Judith C., Farnsworth Norman R., Soejarto Djaja D., Carcache de Blanco Esperanza J.: Cytotoxic and NF-κB inhibitory sesquiterpene lactones from Piptocoma rufescens. Tedrahedron 2012, 68, 2671. <http://dx.doi.org/10.1016/j.tet.2012.01.061>
  • Kim Hyunjung, Krunic Aleksej, Lantvit Daniel, Shen Qi, Kroll David J., Swanson Steven M., Orjala Jimmy: Nitrile-containing fischerindoles from the cultured cyanobacterium Fischerella sp. Tetrahedron 2012, 68, 3205. <http://dx.doi.org/10.1016/j.tet.2012.02.048>
  • Ren Yulin, Wei Min, Still Patrick C., Yuan Shunzong, Deng Youcai, Chen Xiaozhuo, Himmeldirk Klaus, Kinghorn A. Douglas, Yu Jianhua: Synthesis and Antitumor Activity of Ellagic Acid Peracetate. ACS Med. Chem. Lett. 2012, 3, 631. <http://dx.doi.org/10.1021/ml300065z>
  • El-Elimat Tamam, Zhang Xiaoli, Jarjoura David, Moy Franklin J., Orjala Jimmy, Kinghorn A. Douglas, Pearce Cedric J., Oberlies Nicholas H.: Chemical Diversity of Metabolites from Fungi, Cyanobacteria, and Plants Relative to FDA-Approved Anticancer Agents. ACS Med. Chem. Lett. 2012, 3, 645. <http://dx.doi.org/10.1021/ml300105s>
  • Pan Li, Yong Yeonjoong, Deng Ye, Lantvit Daniel D., Ninh Tran Ngoc, Chai Heebyung, Carcache de Blanco Esperanza J., Soejarto Djaja D., Swanson Steven M., Kinghorn A. Douglas: Isolation, Structure Elucidation, and Biological Evaluation of 16,23-Epoxycucurbitacin Constituents from Eleaocarpus chinensis. Journal of Natural Product 2012, 75, 444. <http://dx.doi.org/10.1021/np200879p>
  • Figueroa Mario, Graf Tyler N, Ayers Sloan, Adcock Audrey F, Kroll David J, Yang Jilai, Swanson Steven M, Munoz-Acuna Ulyana, Carcache de Blanco Esperanza J, Agrawal Rajesh, Wani Mansukh C, Darveaux Blaise A, Pearce Cedric J, Oberlies Nicholas H: Cytotoxic epipolythiodioxopiperazine alkaloids from filamentous fungi of the Bionectriaceae. J Antibiot 2012, 65, 559. <http://dx.doi.org/10.1038/ja.2012.69>
  • Sy-Cordero Arlene A, Pearce Cedric J, Oberlies Nicholas H: Revisiting the enniatins: a review of their isolation, biosynthesis, structure determination and biological activities. J Antibiot 2012, 65, 541. <http://dx.doi.org/10.1038/ja.2012.71>
  • Bnouham Mohamed: Recent advances in pharmacologic study of anticancer natural products from medicinal plants in Morocco. TANG 2012, 2, 22.1. <http://dx.doi.org/10.5667/tang.2012.0024>
  • D’Ambrosio Steven M., Han Chunhua, Pan Li, Douglas Kinghorn A., Ding Haiming: Aliphatic acetogenin constituents of avocado fruits inhibit human oral cancer cell proliferation by targeting the EGFR/RAS/RAF/MEK/ERK1/2 pathway. BIOPHYS BIOCHEM RES COMMUN 2011, 409, 465. <http://dx.doi.org/10.1016/j.bbrc.2011.05.027>
  • Chin Young-Won, Chai Hee-Byung, Deng Ye, de Blanco Esperanza Carcache, Kardono Leonardus B.S., Riswan Soedarsano, Soejarto Djaja D., Farnsworth Norman R., Kinghorn A. Douglas: Phytochemical and bioactivity studies on constituents of the leaves of Vitex quinata. Phytochem Lett 2011, 4, 213. <http://dx.doi.org/10.1016/j.phytol.2011.03.007>
  • Ayers Sloan, Ehrmann Brandie M., Adcock Audrey F., Kroll David J., Wani Mansukh C., Pearce Cedric J., Oberlies Nicholas H.: Thielavin B methyl ester: a cytotoxic benzoate trimer from an unidentified fungus (MSX 55526) from the Order Sordariales. Tetrahetron Lett 2011, 52, 5733. <http://dx.doi.org/10.1016/j.tetlet.2011.08.125>
  • Ren Yulin, Matthew Susan, Lantvit Daniel D., Ninh Tran Ngoc, Chai Heebyung, Fuchs James R., Soejarto Djaja D., de Blanco Esperanza J. Carcache, Swanson Steven M., Kinghorn A. Douglas: Cytotoxic and NF-κB Inhibitory Constituents of the Stems of Cratoxylum cochinchinense and Their Semisynthetic Analogues. J Nat Prod 2011, 74, 1117. <http://dx.doi.org/10.1021/np200051j>
  • Ayers Sloan, Graf Tyler N., Adcock Audrey F., Kroll David J., Matthew Susan, Carcache de Blanco Esperanza J., Shen Qi, Swanson Steven M., Wani Mansukh C., Pearce Cedric J.: Resorcylic Acid Lactones with Cytotoxic and NF-κB Inhibitory Activities and Their Structure–Activity Relationships. J Nat Prod 2011, 74, 1126. <http://dx.doi.org/10.1021/np200062x>
  • Kinghorn A. Douglas, Pan Li, Fletcher Joshua N., Chai Heebyung: The Relevance of Higher Plants in Lead Compound Discovery Programs. J Nat Prod 2011, 74, 1539. <http://dx.doi.org/10.1021/np200391c>
  • Sy-Cordero Arlene A., Graf Tyler N., Adcock Audrey F., Kroll David J., Shen Qi, Swanson Steven M., Wani Mansukh C., Pearce Cedric J., Oberlies Nicholas H.: Cyclodepsipeptides, Sesquiterpenoids, and Other Cytotoxic Metabolites from the Filamentous Fungus Trichothecium sp. (MSX 51320). Journal of Natural Product 2011, 74, 2137. <http://dx.doi.org/10.1021/np2004243>
  • Pan Li, Lantvit Daniel D., Riswan Soedarsono, Kardono Leonardus B.S., Chai Hee-Byung, Carcache de Blanco Esperanza J., Farnsworth Norman R., Soejarto Djaja Doel, Swanson Steven M., Kinghorn A. Douglas: Bioactivity-guided isolation of cytotoxic sesquiterpenes of Rolandra fruticosa. Phytochemisry 2010, 71, 635. <http://dx.doi.org/10.1016/j.phytochem.2010.01.012>
  • Ren Yulin, Lantvit Daniel D., Carcache de Blanco Esperanza J., Kardono Leonardus B.S., Riswan Soedarsono, Chai Heebyung, Cottrell Charles E., Farnsworth Norman R., Swanson Steven M., Ding Yuanqing, Li Xing-Cong, Marais Jannie P.J., Ferreira Daneel, Kinghorn A. Douglas: Proteasome-inhibitory and cytotoxic constituents of Garcinia lateriflora: absolute configuration of caged xanthones. Tetrahedron 2010, 66, 5311. <http://dx.doi.org/10.1016/j.tet.2010.05.010>
  • Sy-Cordero Arlene A, Graf Tyler N, Wani Mansukh C, Kroll David J, Pearce Cedric J, Oberlies Nicholas H: Dereplication of macrocyclic trichothecenes from extracts of filamentous fungi through UV and NMR profiles. J Antibiot 2010, 63, 539. <http://dx.doi.org/10.1038/ja.2010.77>